52-56 Cenesiz Rabbit May 2 0640.fm

Twenty healthy 6-month-old male and female New Zealand rabbits with a mean body weight of 3.5±0.5 kg were fed a standard commercial rabbit diet and provided with water ad libitum containing 40 mg F/L for 70 days. Blood samples were obtained from each rabbit, and sera adenosine deaminase (ADA) activity and Creactive protein (CRP) and ceruloplasmin (CP) levels were determined with the following results at the start, at day 35, and at day 70, respectively: ADA activity 9.55±0.66, 14.78±1.11, and 19.56±1.85 U/L; CRP level 18.1±2.6, 85.5±20.3, and 123±23.26 ng/mL; CP level 22.19±2.66, 19.49±1.18, and 14.75± 0.96 mg/dL. By days 35 and 70 significant increases in ADA activity and CRP levels had occurred, along with a significant decrease in the CP level. These results demonstrated that fluoride intoxication caused significant alterations in ADA, CRP, and CP in rabbit sera.